S100B Promotes Glioma Growth through Chemoattraction of Myeloid-Derived Macrophages
نویسندگان
چکیده
منابع مشابه
S100B promotes glioma growth through chemoattraction of myeloid-derived macrophages.
PURPOSE S100B is member of a multigenic family of Ca(2+)-binding proteins, which is overexpressed by gliomas. Recently, we showed that low concentrations of S100B attenuated microglia activation through the induction of Stat3. We hypothesized that overexpression of S100B in gliomas could promote tumor growth by modulating the activity of tumor-associated macrophages (TAM). EXPERIMENTAL DESIGN...
متن کاملHuman Cancer Biology S100B Promotes GliomaGrowth throughChemoattraction of Myeloid-Derived Macrophages
Purpose: S100B is member of a multigenic family of Ca2þ-binding proteins, which is overexpressed by gliomas. Recently, we showed that low concentrations of S100B attenuatedmicroglia activation through the induction of Stat3. We hypothesized that overexpression of S100B in gliomas could promote tumor growth by modulating the activity of tumor-associated macrophages (TAM). Experimental Design:We ...
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ژورنال
عنوان ژورنال: Clinical Cancer Research
سال: 2013
ISSN: 1078-0432,1557-3265
DOI: 10.1158/1078-0432.ccr-12-3725